Hydocs polytetrafluoroethylene (PTFE) pleated filter cartridge is made of high-porosity hydrophobic PTFE membrane, which has the characteristics of high flux and long service life. Its wide chemical resistance makes PTFE filter cartridge especially suitable for sterilizing filtration of various low surface tension chemicals and gases, and hydrophilic polytetrafluoroethylene pleated filter cartridges can be provided, which can be used for filtration of various strong acid and alkali solutions without wetting.